Linagliptin: medicine to treat type 2 diabetes - NHS.
Our data also demonstrate that linagliptin can induce OPC proliferation and differentiation, and enhance remyelination as indicated by increased Olig2 gene expression. Oligodendrocytes are the most vulnerable brain cells to oxidative stress due to its high metabolic demand for synthesizing myelin sheaths (Ichinose et al., 2014), and relatively low levels of antioxidants (Lassmann and Van.
A group of 523 patients took linagliptin and 177 took placebo. From a baseline of 8.09%, the HbA1c reduced by 0.49% with linagliptin 5 mg and increased by 0.15%, from 8.02%, with placebo. A target HbA1c of 7% or less was achieved by 26% of the linagliptin group and 9% of the placebo group. 2.
Linagliptin is a dipeptidyl peptidase-4 inhibitor and is used for the treatment of type 2 diabetes. It is a type of antidiabetic medication should be taken along with proper diet and exercise. As alone it is not sufficient to control and curb diabetes.
Linagliptin(Tradjenta) generic is a dipeptidyl peptidase-4 (DPP-4) inhibitor, prescribed for type 2 diabetes. It increases insulin secretion by pancreas.
Linagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP-4 Linagliptin increases the concentrations of active incretin hormones and stimulates the release of Insulin in a glucose dependent manner and decreases the level of Glucagon in the circulation and thus.
Linagliptin, one of the five dipeptidyl peptidase-4 inhibitors available, has recently entered the market both in the US and in most European countries for treatment of type 2 diabetes mellitus. It presents a xanthine-based structure, and is characterized by unique pharmacokinetics, with non-linear profile, long terminal half-life allowing prolonged exposure to the drug.
Linagliptin and Mechanism of Action. Patient was educated on Linagliptin and its mechanism of action as follows: Rise in the blood sugars stimulates release of a natural hormone in the human body, called Incretin. Incretin brings about the secretion of insulin from the pancreas and insulin helps with uptake of glucose by the tissues and lowers the blood glucose. As the blood sugar decreases.