Beyond binding: antibody effector functions in infectious.
Introduction to Immunoglobulins.. This switch does not affect the antibody’s specificity for its antigen, but it does alter the effector functions that each class of antibody can execute. The antibody class switch is critically dependent on the type of cytokine that is present. Various cytokines, such as IL-4, IL-5, IFN-gamma and TGF-beta.
A molecular explanation of antibody effector function requires the description of multiple antibody molecules cross-linking an array of antigen molecules to multiple effector molecules.
Antibodies (ISSN 2073-4468; CODEN: ANTICA) is an international peer-reviewed open access journal on immunoglobulins published quarterly online by MDPI. Open Access free for readers, with article processing charges (APC) paid by authors or their institutions.; High Visibility: Indexed in the Emerging Sources Citation Index (ESCI - Web of Science), EMBASE (Elsevier) and other databases.
The importance of antigens and antibodies. The red cells of an individual contain antigens on their surfaces that correspond to their blood group and antibodies in the serum that identify and combine with the antigen sites on the surfaces of red cells of another type. The reaction between red cells and corresponding antibodies usually results in clumping— agglutination—of the red cells.
Define what cytokines are and their function in the immune system Examine the five different types of cytokines found in the body: chemokines, interferons, interleukins, lymphokines, and tumor.
Because IgM antibodies can implement fewer effector functions than IgG antibodies, which constitute the main class of antibody produced in an adaptive immune response, one would expect that immunity would be impaired. In addition, no IgA antibodies could be produced, leaving the person highly vulnerable to infection through mucosal surfaces.
T cell, type of leukocyte (white blood cell) that is an essential part of the immune system. T cells are one of two primary types of lymphocytes—B cells being the second type—that determine the specificity of immune responses to antigens (foreign substances) in the body.